career opportunities at pulmatrix

Pulmatrix is looking for individuals with the skills and talents that will most effectively contribute to our mission of advancing novel therapeutics that have significant potential to transform how we address respiratory diseases.

We are a committed and energetic team, at work and at play! Our culture affords us enjoyment and appreciation for each other, while providing a strong support network and respectful work environment.

Pulmatrix is an Equal Opportunity Employer, and offers a comprehensive benefits package, including health, dental, and life insurance, paid vacation and a 401(k) investment plan.


Career Opportunities Currently Available:
Sr. Scientist I/II
Analytical Development

 

At Pulmatrix, we are developing innovative inhaled therapies to address serious pulmonary disease using our clinically validated, proprietary iSPERSE technology. Leveraging the unique capabilities of iSPERSE to dramatically advance inhalation technology, we can create new therapies to improve patient outcomes.


Our pipeline of inhaled therapies represents innovative, first-in-class products. Our proprietary pipeline of novel therapies for respiratory diseases is led by PUR1900, PUR1800 and PUR5700. PUR1900 is an inhaled anti-infective to treat ABPA in severe asthmatics and cystic fibrosis patients. PUR1800 and PUR5700 are novel inhaled anti-inflammatory compounds that selectively inhibit kinases involved in inflammation. PUR1800 is being developed to treat and prevent exacerbations in patients with chronic obstructive pulmonary disease (COPD) and PUR5700 is being explored as a therapy for COPD, asthma and IPF. Our pipeline in major pulmonary diseases developed in collaboration with partners is led by PUR0200, a branded generic in clinical development for COPD.


iSPERSE is a, dry powder technology developed, patented and validated by Pulmatrix scientists and engineers to improve how drugs are directed into the lungs. iSPERSE products are designed to maximize local drug concentrations and reduce systemic side effects, in order to make possible a new generation of inhaled therapies to improve patient outcomes.


Overall Responsibility:

We are seeking an exceptional Sr.Scientist to be a key member of the Analytical Development group. This position will lead an analytical chemistry group in the development and implementation of a range of analytic testing methods for the characterization of our solid-based inhalation dosage formulations for use in early stage clinical trials. The ideal candidate will possess a demonstrated expertise in analytical characterization of APIs (small and/or large molecule) and drug products. Further, the candidate will report to the head of Analytical Development and will be expected to apply strong organizational and communication skills to assist with method development, preparation of testing protocols and performing analyses to help drive the advancement of our product development programs both internal and external.


The work environment is highly collaborative, requires excellent communication skills and the ability to be part of a cross-functional product development team. The successful candidate must have previous analytical development experience in support of pharmaceutical product development. The candidate is expected to support to our CMC strategy for novel pulmonary formulations through contributionto the CMC project teams and have a proven ability to meet development goals within aggressive timelines.


Key Technical Skills:
  • Command of chemistry and analytical chemistry principles including but not limited to FTIR, NMR and ICP-MS.
  • Experience in the applied use of different chromatographic techniques (HPLC/UPLC/GC), LC/MSas well asUV-Vis, KF Moisture analysis and associated hardware and computer interfaces with an emphasis on small molecule analysis
  • Proficient in the use of wet chemistry techniques and general analytical laboratory equipment
  • Experience in the development and execution of methods focused on aerosol characterization or characterization of inhaled drug products is a strong plus
  • Ability to independently plan, execute and document method development, analyses and qualification assessment activities related to drug product development.
  • Experienced with the Waters HPLC systems and Empower strongly desired
  • Strong qualitative and quantitative data analysis and interpretation skills following good analytical laboratory practices and an understanding of cGMP/cGDP
  • Knowledge of ICH analytical method guidelines are required
  • Expected to supervise and provide guidance and supervision to junior scientist(s) in your team.
Key Personal Skills:

Minimum of a scientific Bachelor’s degree (Chemistry, Analytic Chemistry, Biochemistry or related field) and 10 years of relevant industry experience in biotech/pharmaceutical R&D, M.Sc. with 8+ years or PhD with 5+ yearsof experience. A combination of experience and/or education will be taken into consideration for position and title.


  • May require travel
  • Must be authorized to work in the United States for any employer without the need for sponsorship

Contact: jobs@pulmatrix.com with cover letter and CV

Engineering Associate // Senior Engineering Associate
Pharmaceutical Development

 
At Pulmatrix, we are developing innovative inhaled therapies to address serious pulmonary disease using our clinically validated, proprietary iSPERSE technology. Leveraging the unique capabilities of iSPERSE to dramatically advance inhalation technology, we can create new therapies to improve patient outcomes.

Our pipeline of inhaled therapies represents innovative, first-in-class products. Our proprietary pipeline of novel therapies for respiratory diseases is led by PUR1900, PUR1800 and PUR5700. PUR1900 is an inhaled anti-infective to treat ABPA in severe asthmatics and cystic fibrosis patients. PUR1800 and PUR5700 are novel inhaled anti-inflammatory compounds that selectively inhibit kinases involved in inflammation. PUR1800 is being developed to treat and prevent exacerbations in patients with chronic obstructive pulmonary disease (COPD) and PUR5700 is being explored as a therapy for COPD, asthma and IPF. Our pipeline in major pulmonary diseases developed in collaboration with partners is led by PUR0200, a branded generic in clinical development for COPD.

iSPERSE is a, dry powder technology developed, patented and validated by Pulmatrix scientists and engineers to improve how drugs are directed into the lungs. iSPERSE products are designed to maximize local drug concentrations and reduce systemic side effects, in order to make possible a new generation of inhaled therapies to improve patient outcomes.

Overall Responsibility:
We are seeking a highly motivated engineer to join the Pharmaceutical Development group supporting process development for respiratory drug products.

Responsibilities:
  • Support development and optimization of engineered particle inhaled dosage forms. Specific methods may include bench and pilot-scale spray drying
  • Support development of new technologies
  • Perform physicochemical property and aerosol performance characterization of solid-based inhalation dosage forms
  • Support batch manufacture for development, pre-clinical and clinical studies
Skills:
  • Strong engineering fundamentals
  • Excellent problem solving and data analysis skills
  • Excellent oral and written communication skills
  • Attention to detail
  • Fluency in MS Office software
  • Accuracy in following instructions, generating data, and documenting data and procedures
  • Experience with general laboratory procedures
  • Demonstrated mechanical and/or electronics aptitude, or previous experience with pilot labs or hands-on controls engineering, is a plus
  • Familiarity/experience with particle engineering and/or spray drying is a plus
Education & Experience:
  • BS/BA or MS in Chemical Engineering, Biomedical Engineering, or related field
  • 1-5 years of experience in biotech/pharmaceutical R&D

Contact: jobs@pulmatrix.com with cover letter and CV



 
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