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iCALM therapies are uniquely able to deliver multiple benefits through distinct mechanisms of action which enhance and stimulate the inherent biophysical and biochemical properties of the airway:
 - Creating a biophysical barrier in the lungs to prevent infection, and reduce
contagion;
- Enhancing the clearance of pathogens;
- Stimulating host defense mechanisms; and
- Reducing inflammation.
- iCALM therapies alter the three dimensional matrices (or conformation) of
endogenous glycoproteins, resulting in enhanced barrier function in the lung
and reducing the penetration of pathogens into the lung tissue;
- Reduce bioaerosol formation from the mucus layer, reducing the formation and
exhalation of airborne infectious agents and further spread of infectious disease;
- Increase mucus hydration by drawing water into and thinning the airway mucus
layer; this thinner mucus is more easily cleared from the airway, reducing the
opportunity of entrapped pathogens to induce infection;
- Increase movement of cilia that line the airway, which “beat” to move pathogens
up and out of the lungs, expelling pathogens faster.
- Act through the modulation of ion channel activity to stimulate the release of
innate immune proteins including antimicrobial peptides;
- Dampen the airway and epithelial response to infection, aeroallergens, or lung
injury, reducing airway inflammation. |
