The demonstrated broad-spectrum efficacy and the promise of safety for Pulmatrix's iCALM therapies could allow them to be administered as treatment or preventative measures, in high risk settings, or even as a first-line of defense to respond to traditional and emerging infectious agents. Further, Pulmatrix drugs have the potential for use as chronic maintenance therapies in patients with underlying pulmonary disease, and in other indications where prophylactic intervention may mitigate serious clinical consequences of infection.
ICALM therapies have potential for use in many respiratory diseases including:
Influenza, commonly referred to as the flu, is a viral infectious disease with prominent and sometimes severe respiratory symptoms. The most common symptoms of the illness are fever, chills, cough, severe headache, sore throat, muscle pains, and profound weakness/fatigue. In severe cases, it can cause shortness of breath and respiratory failure.
Influenza-like illness (ILI), also known as acute respiratory infection and flu-like syndrome, is a medical diagnosis of possible influenza or illness causing symptoms typical of influenza. It can be caused by a number of other respiratory viruses.
Ventilator-associated pneumonia (VAP) is a sub-type of hospital-acquired pneumonia (HAP) which occurs in people who are on mechanical ventilation through an endotracheal or tracheostomy tube. It is usually caused by bacteria that invade the respiratory tract and, often, these bacteria are resistant to many antibiotics.
Respiratory syncytial virus (RSV) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children. It can be more serious in young babies and infants, especially those born prematurely or who have respiratory or heart conditions at birth.
Rhinovirus is the most common respiratory virus in humans and is the cause of the common cold, and more severe illness in patients with lung conditions.
Adenovirus infections most commonly cause illness of the respiratory system; however, depending on the infecting serotype, they may also cause illness that affects other body systems, including gastroenteritis, conjunctivitis, cystitis, and rashes. Respiratory illness caused by adenovirus range from the common cold to croup, bronchitis, and pneumonia.
Parainfluenza is the second most common cause of lower respiratory tract infection in younger children. This virus is the most common cause of croup in children.
Chronic Obstructive Pulmonary Disease (COPD) is a condition marked by inflammation and destruction of the airways and lung, typically brought about by longstanding smoking. Persons affected by COPD have prominent symptoms of cough, phlegm, shortness of breath and exercise limitation. Pulmonary exacerbations (worsening of respiratory symptoms caused principally by viral infections), are a major contributor to the health care costs and serious consequences (hospitalization, death) for COPD patients.
Asthma is an inflammatory disorder of the airways, which causes attacks of wheezing, shortness of breath, chest tightness, and coughing. Asthma therapy is directed at controlling airway inflammation, reversing bronchoconstriction, and preventing or decreasing the severity of exacerbations which are frequently caused by respiratory infections.
Cystic Fibrosis (CF) is an inherited disease that causes thick, sticky mucus to build up in the lungs and digestive tract. It is the most common severe chronic lung diseases in children and young adults, and usually results in shortened life expectancy due to progressive respiratory infection and lung damage.
Allergic Rhinitis is an allergic disorder caused by chronic or acute inflammation of the nasal mucous membranes triggered by pollen, mold, animal dander, dust and other similar inhaled allergens. It can occur seasonally or all year round, depending of the offending allergen trigger.
- influenza-like illness (ILI) »